| Sunnyside | 2019 | actor |
| Scooby-Doo and Guess Who? | 2019 | actor |
| The Klepper Podcast | 2019 | actor |
| Blindspot | 2018-2019 | actor |
| The Big Bang Theory | 2013-2018 | actor |
| What's Popping Up?! with Alana Jordan | 2018 | actor |
| Fiksiki: Bolshoy sekret | 2017 | actor |
| Futurama: Worlds of Tomorrow | 2017 | actor |
| Mission Force One | 2015-2017 | actor |
| Quick Reviews with Maverick | 2016 | actor |
| Inside Amy Schumer | 2015 | actor |
| Bill Nye the Science Guy Tackles DeflateGate | 2015 | actor |
| The (206) | 2013-2014 | actor |
| The Neighbors | 2014 | actor |
| Tosh.0 | 2014 | actor |
| The Drunken Peasants | 2014 | actor |
| Stargate: Atlantis | 2008 | actor |
| Numb3rs | 2005-2008 | actor |
| Rocketboy | 2006 | actor |
| The Eyes of Nye | 2005 | actor |
| 100 Greatest Discoveries | 2004 | actor |
| BattleBots | 2000 | actor |
| Get Real | 2000 | actor |
| The Wonderful World of Disney | 1998 | actor |
| Back to the Future | 1991-1992 | actor |
| The All New Mickey Mouse Club | 1989 | actor |
| Almost Live! | 1984 | actor |
| StarTalk | 2017-2018 | writer |
| Bill Nye Saves the World | 2017 | writer |
| Stuff Happens Hosted by Bill Nye | | writer |
| The Eyes of Nye | 2005 | writer |
| Absent Minded Inventions and the Search for Flubber with Bill Nye the Science Guy | 1997 | writer |
| Bill Nye, the Science Guy | | writer |
| Flubber | 1997 | miscellaneous |
| American Experience | 1991-1996 | miscellaneous |
| Degenerate Art | 1993 | miscellaneous |
| Bill Nye Saves the World | 2017 | producer |
| Bill Nye, the Science Guy | 1995 | producer |
| Whose Line Is It Anyway? | 2015 | soundtrack |
| Physics Girl | 2016 | thanks |
| For the Love of Spock | 2016 | thanks |
| The Confirmation | 2016 | thanks |
| Cuomo Prime Time | 2019 | self |
| WE Day | 2019 | self |
| Ok! TV | 2019 | self |
| The Klepper Podcast | 2019 | self |
| Last Week Tonight with John Oliver | 2014-2019 | self |
| StarTalk | 2015-2019 | self |
| A Brief History of Time Travel | 2018 | self |
| Mars | 2018 | self |
| 24 Hours of Reality: Protect Our Planet, Protect Ourselves | 2018 | self |
| 2018 Primetime Creative Arts Emmy Awards | 2018 | self |
| Last Call with Carson Daly | 2018 | self |
| Bill Nye Saves the World | 2017-2018 | self |
| The Joel McHale Show with Joel McHale | 2018 | self |
| A.P. Bio | 2018 | self |
| Beyond Stranger Things | 2017 | self |
| The Opposition with Jordan Klepper | 2017 | self |
| Watch the Falcon Heavy and LightSail Launch with Bill Nye | 2017 | self |
| 2017 Primetime Creative Arts Emmy Awards | 2017 | self |
| ABC News Specials | 2017 | self |
| CBS This Morning | 2012-2017 | self |
| CBS News Sunday Morning | 2016-2017 | self |
| Penn Zero: Part-Time Hero | 2017 | self |
| Future-Worm! | 2017 | self |
| The Late Show with Stephen Colbert | 2017 | self |
| 9th Annual Shorty Awards | 2017 | self |
| WIRED Magazine: Bill Nye Answers Science Questions from Twitter | 2017 | self |
| Today | 2017 | self |
| The View | 2013-2017 | self |
| Nye/Ham: The Second Debate | 2017 | self |
| Bill Nye: Science Guy | 2017 | self |
| The Mars Generation | 2017 | self |
| The Timeline | 2016 | self |
| Red Carpet Report | 2016 | self |
| Rogue One: A Star Wars Story - World Premiere | 2016 | self |
| Talk Stoop | 2016 | self |
| Star Trek: Inside the Roddenberry Vault | 2016 | self |
| Food Evolution | 2016 | self |
| Fight for Space | 2016 | self |
| Physics Girl | 2016 | self |
| The Journey to Mars 101: Living on Mars and Beyond | 2016 | self |
| Chelsea | 2016 | self |
| The Nightly Show with Larry Wilmore | 2015-2016 | self |
| Independent Lens | 2016 | self |
| Explorer | 2015 | self |
| Global Citizen Festival | 2015 | self |
| Whose Line Is It Anyway? | 2015 | self |
| 7th Annual Shorty Awards | 2015 | self |
| Night of Too Many Stars: America Comes Together for Autism Programs | 2015 | self |
| Real Time with Bill Maher | 2013-2015 | self |
| Inside Edition | 2014 | self |
| Up with Steve Kornacki | 2014 | self |
| Late Night with Seth Meyers | 2014 | self |
| An Honest Liar | 2014 | self |
| The Independents | 2014 | self |
| The Secret Life of Scientists and Engineers | 2014 | self |
| Katie | 2014 | self |
| ABC News Nightline | 2014 | self |
| ABC World News Tonight with David Muir | 2014 | self |
| Piers Morgan Tonight | 2013-2014 | self |
| Uncensored Science: Bill Nye Debates Ken Ham | 2014 | self |
| King of the Nerds | 2014 | self |
| Stossel | 2012-2014 | self |
| Politics Nation with Al Sharpton | 2014 | self |
| On Begley Street | 2013 | self |
| Dancing with the Stars | 2013 | self |
| Hub Network's First Annual Halloween Bash | 2013 | self |
| Why with Nye | 2013 | self |
| The Arsenio Hall Show | 2013 | self |
| Good Morning America | 2013 | self |
| The Nerdist | 2013 | self |
| Larry King Now | 2013 | self |
| EcoDivas TV | 2012-2013 | self |
| Safety Smart Science with Bill Nye the Science Guy: Renewable Energy | 2012 | self |
| Solution Earth a New Beginning | 2012 | self |
| The War Room with Michael Shure | 2012 | self |
| Sandy: The Anatomy of a Superstorm | 2012 | self |
| Alien Deep with Bob Ballard | 2012 | self |
| Safety Smart Science with Bill Nye the Science Guy | 2011 | self |
| Living with Ed | 2007-2009 | self |
| Solving for X | 2009 | self |
| Who Wants to Be a Millionaire | 2008-2009 | self |
| Nova | 2009 | self |
| The Bonnie Hunt Show | 2008 | self |
| Gravity's Effect on Humans with Bill Nye the Science Guy | 2008 | self |
| Stuff Happens Hosted by Bill Nye | 2008 | self |
| America's Most Smartest Model | 2007 | self |
| Greatest Inventions with Bill Nye | 2007 | self |
| Last Stop Kew Gardens | 2006 | self |
| This Week | 2006 | self |
| The Late Late Show with Craig Ferguson | 2005 | self |
| Larry King Live | 2005 | self |
| TV Land's Top Ten | 2005 | self |
| First Look | 2004 | self |
| VH1 Big in 03 | 2003 | self |
| Countdown to Mars | 2003 | self |
| Bill Nye and Debbie Allen Imagine Mars | 2002 | self |
| Win Ben Stein's Money | 2001 | self |
| Turn Ben Stein On | 2000 | self |
| The Martin Short Show | 1999 | self |
| Hollywood Squares | 1999 | self |
| The Rosie O'Donnell Show | 1999 | self |
| The 26th Annual Daytime Emmy Awards | 1999 | self |
| Bill Nye, the Science Guy | 1993-1998 | self |
| The 25th Annual Daytime Emmy Awards | 1998 | self |
| Late Night with Conan O'Brien | 1998 | self |
| Absent Minded Inventions and the Search for Flubber with Bill Nye the Science Guy | 1997 | self |
| Astronauts | 1997 | self |
| Mister Rogers' Neighborhood | 1997 | self |
| Crook & Chase | 1996 | self |
| Ellen's Energy Adventure | 1996 | self |
| Space Ghost Coast to Coast | 1996 | self |
| Walt Disney World Inside Out | 1994 | self |
| The All New Mickey Mouse Club | 1989 | self |
| Front Runners | 1986 | self |
| Tucker Carlson Tonight | 2019 | archive_footage |
| Real Eyes Realize Real Lies | 2018 | archive_footage |
| Behind the Curve | 2018 | archive_footage |
| Democracy Now! | 2017 | archive_footage |
| Unacknowledged | 2017 | archive_footage |
| Physics Girl | 2017 | archive_footage |
| Watters' World | 2017 | archive_footage |
| Before the Flood | 2016 | archive_footage |
| The Drunken Peasants | 2014-2015 | archive_footage |
| The Comfort Zone | 2013-2014 | archive_footage |
| Mike & Mike | 2013 | archive_footage |
| In Focus | 2012 | archive_footage |
| Some Jerk with a Camera | 2012 | archive_footage |
| Pastor Mike Online | 2012 | archive_footage |
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