| King Knight | 2020 | actor |
| Horse Girl | 2020 | actor |
| Criminal Minds | 2005-2020 | actor |
| Dollface | 2019 | actor |
| Endings, Beginnings | 2019 | actor |
| Camp Confessions | 2018 | actor |
| Zoe | 2018/I | actor |
| 68 Kill | 2017 | actor |
| Newness | 2017 | actor |
| Hot Air | 2016/II | actor |
| Trash Fire | 2016 | actor |
| Alvin and the Chipmunks: The Road Chip | 2015 | actor |
| Band of Robbers | 2015 | actor |
| Desire | 2014/II | actor |
| Beautiful Girl | 2014 | actor |
| Batman: Assault on Arkham | 2014 | actor |
| Suburban Gothic | 2014 | actor |
| El Hormiguero MX | 2014 | actor |
| The Learning Curve | 2014 | actor |
| Life After Beth | 2014 | actor |
| The Beauty Inside | 2012 | actor |
| The Beauty Inside: Alex's Video Diaries | 2012 | actor |
| Excision | 2012 | actor |
| Alvin and the Chipmunks: Chipwrecked | 2011 | actor |
| Magic Valley | 2011 | actor |
| Scooby-Doo! Legend of the Phantosaur | 2011 | actor |
| All-Star Superman | 2011 | actor |
| Alvin and the Chipmunks: The Squeakquel | 2009 | actor |
| 500 Days of Summer | 2009 | actor |
| How to Be a Serial Killer | 2008 | actor |
| The Great Buck Howard | 2008 | actor |
| Alvin and the Chipmunks | 2007 | actor |
| Matthew Gray Gubler: The Unauthorized Documentary | 2006 | actor |
| RV | 2006 | actor |
| The Life Aquatic with Steve Zissou | 2004 | actor |
| Criminal Minds | 2010-2018 | director |
| The Killers: Dirt Sledding | 2015 | director |
| The Killers: Don't Shoot Me Santa | 2007 | director |
| Matthew Gray Gubler: The Unauthorized Documentary | 2006 | director |
| Claude: A Symphony of Horror | 2005 | director |
| The Cactus That Looked Just Like a Man | 2005 | director |
| Matthew Gray Gubler's Life Aquatic Intern Journal | 2005 | director |
| King Knight | 2020 | producer |
| The Killers: Dirt Sledding | 2015 | producer |
| Band of Robbers | 2015 | producer |
| Matthew Gray Gubler: The Unauthorized Documentary | 2006 | producer |
| The Cactus That Looked Just Like a Man | 2005 | producer |
| Matthew Gray Gubler's Life Aquatic Intern Journal | 2005 | producer |
| Matthew Gray Gubler: The Unauthorized Documentary | 2006 | writer |
| The Cactus That Looked Just Like a Man | 2005 | writer |
| Matthew Gray Gubler's Life Aquatic Intern Journal | 2005 | writer |
| The Killers: Don't Shoot Me Santa | 2007 | editor |
| The Cactus That Looked Just Like a Man | 2005 | editor |
| Matthew Gray Gubler's Life Aquatic Intern Journal | 2005 | editor |
| The Cactus That Looked Just Like a Man | 2005 | cinematographer |
| Matthew Gray Gubler's Life Aquatic Intern Journal | 2005 | cinematographer |
| Queen of the Parade | 2013 | thanks |
| This Is an Adventure | 2005 | thanks |
| Camp Confessions | 2019 | self |
| The Talk | 2014-2019 | self |
| Criminal Minds: Season 13 - Thirteen Minds | 2018 | self |
| Criminal Minds Season 13 - Mixed Signals: The Table Read | 2018 | self |
| Criminal Minds: Season 12 - The Family Unit | 2017 | self |
| Criminal Minds: Season 12 - The Prisoner | 2017 | self |
| Criminal Minds - Season 11: The Dirty Eleven | 2016 | self |
| Criminal Minds - Season 11: To Derek, with Love | 2016 | self |
| Made in Hollywood | 2016 | self |
| @midnight | 2016 | self |
| Criminal Minds: Season 10 - Criminal Minds Top Ten | 2015 | self |
| The Playboy Morning Show | 2015 | self |
| Criminal Minds: Season 9 - Eyes Only | 2014 | self |
| That's My Entertainment | 2014 | self |
| Criminal Minds: Season 8 - Beautiful Minds | 2013 | self |
| Criminal Minds: Season 8 - The Profiler's Handbook: Peter Pan Syndrome | 2013 | self |
| 81st Annual Hollywood Christmas Parade | 2012 | self |
| The Late Late Show with Craig Ferguson | 2012 | self |
| Criminal Minds Season 7: Fireside Chat with Matthew Gray Gubler | 2012 | self |
| Criminal Minds Season 7: Minds' Eye - Bloodlust | 2012 | self |
| Criminal Minds Season 7: Minds' Eye - Devil Inside | 2012 | self |
| Criminal Minds Season 7: Minds' Eye - Implosion | 2012 | self |
| Criminal Minds Season 7: Minds' Eye - The Fall | 2012 | self |
| Criminal Minds Season 7: Minds' Eye - Too Big to Fail | 2012 | self |
| Criminal Minds Season 7: Minds' Eye - Twisted | 2012 | self |
| Criminal Minds Season 7: Seven Stories | 2012 | self |
| Criminal Minds Season 7: Wedding Toasts | 2012 | self |
| Criminal Minds Season 6: Crime Scene - Death Cab | 2011 | self |
| Criminal Minds Season 6: Crime Scene - Devil in the Details | 2011 | self |
| Criminal Minds Season 6: Crime Scene - Love Is Explosive | 2011 | self |
| Criminal Minds Season 6: Crime Scene - The Deep End | 2011 | self |
| Criminal Minds Season 6: From Script to Screen - Agent Down | 2011 | self |
| Criminal Minds Season 6: Secrets - Making of Criminal Minds | 2011 | self |
| Celebrity Ghost Stories | 2011 | self |
| The Daily Habit | 2011 | self |
| Criminal Minds Season 5: Case Files - Break | 2010 | self |
| Criminal Minds Season 5: Case Files - Dante | 2010 | self |
| Criminal Minds Season 5: Case Files - Darkness | 2010 | self |
| Criminal Minds Season 5: Case Files - Deserted | 2010 | self |
| Criminal Minds Season 5: Case Files - Grim | 2010 | self |
| Criminal Minds Season 5: Case Files - Subjects Unknown | 2010 | self |
| Criminal Minds Season 5: Material Witness | 2010 | self |
| Criminal Minds Season 5: Celebrating 100 | 2010 | self |
| Criminal Minds Season 5: Fear the Reaper | 2010 | self |
| Criminal Minds Season 5: Gubler Direct | 2010 | self |
| Swan... One Man's Journey | 2010 | self |
| Working the Scene: A Look Behind the Scenes of 'Criminal Minds Season 4' | 2009 | self |
| Criminal Minds Season 3: Killer Roles | 2008 | self |
| From Script to Screen: True Night | 2008 | self |
| Profile: Rossi/Mantegna | 2008 | self |
| Shemar Moore: Criminal Minds' Wild Ride | 2008 | self |
| The Criminal Element: The Making of 'Criminal Minds, Season 3' | 2008 | self |
| Profilers, Profiled | 2007 | self |
| Up Close with Carrie Keagan | 2007 | self |
| Meet Matthew Gray Gubler | 2006 | self |
| The 32nd Annual People's Choice Awards | 2006 | self |
| CBS Cares | 2005-2006 | self |
| Matthew Gray Gubler's Life Aquatic Intern Journal | 2005 | self |
| Welcome to the Basement | 2015 | archive_footage |
40